Pair Name	Zerumbone, Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	EGFR	hsa1956
	Down-regulation	Expression	GPX4	hsa2879
	Down-regulation	Expression	KDR	hsa3791
	Down-regulation	Expression	SLC7A11	hsa23657
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	VEGFA	hsa7422
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
	NCI-H460	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0459
In Vivo Model	The mice were injected with 1×10⁷ cell/mL A549 cells (0.2ml/mice) into the left axilla.
Result	Our study suggested that zerumbone combined with gefitinib could effectively inhibit lung cancer for multi-model therapies, including the inhibition of tumor growth, angiogenesis, induce cell apoptosis, and ferroptosis.